Neutropenia in patients with HIV infection: a case control study in a cohort of 1403 patients between 1982 and 1993
| Autor: | Nathalie Van Cutsem, Bernadette Sommereijns, Philippe Hermans, Nathan Clumeck |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutropenia Databases Factual Immunology Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Cohort Studies Leukocyte Count Risk Factors Internal medicine medicine Humans In patient Lymphocyte Count Stage (cooking) Aged Retrospective Studies Acquired Immunodeficiency Syndrome business.industry Case-control study Hematology Bacterial Infections Middle Aged medicine.disease CD4 Lymphocyte Count Mycoses Bacteremia Case-Control Studies Cohort Absolute neutrophil count Female business |
| Zdroj: | Journal of hematotherapystem cell research. 8 |
| ISSN: | 1525-8165 |
| Popis: | The relationship between neutropenia and increased risks of severe infections in patients with HIV infection and the factors associated with neutropenia-induced infections was studied by a retrospective comparative study using matched case-control analysis. A database (1982-1993) of 1870 patients with HIV infection was searched, and from 484 patients with neutropenia, 177 patients were paired with 177 nonneutropenic control subjects. Descriptive analysis and development of logistic models were used to determine factors associated with the risk of developing bacterial infections and major fungal infections. The occurrence of severe bacterial and fungal infections was significantly higher in neutropenic patients (por = 0.001). Bacteremia was more common in neutropenic patients than in nonneutropenic patients (por = 0.02) in the matched case-control analysis. Risk of severe infections was strongly associated with the neutrophil count (por = 0.05), clinical stage, and hemoglobin level (p0.005) when paired patients were compared. More neutropenic episodes occurred between 1991 to 1993, possibly due to prolonged survival and the increasing use of concomitant myelosuppressive therapies. Neutropenic HIV-infected patients are significantly at risk of developing severe infections at the end-stage of HIV disease, and this may have a major impact on hospitalization and death. Preventing neutropenia could dramatically improve the quality of life of these patients. |
| Databáze: | OpenAIRE |
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