Magnetic resonance imaging-three-dimensional printing technology fabricates customized scaffolds for brain tissue engineering
| Autor: | Li-Na Wang, Xu-Yi Chen, Feng Fu, Hong-Tao Sun, Ding-wei Peng, Xiao-Hong Li, Yue Tu, Sai Zhang, Ming-liang Zhao, Zhe Qin, Li Ruixin, Chao Xu, Chong Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
collagen
Fabrication Materials science Biocompatibility 0206 medical engineering 02 engineering and technology Brain tissue lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Tissue engineering Fabrication methods medicine magnetic resonance imaging three-dimensional printing nerve regeneration lcsh:Neurology. Diseases of the nervous system medicine.diagnostic_test mimics Manufacturing process traumatic brain injury Magnetic resonance imaging 020601 biomedical engineering Three dimensional printing tissue engineering scaffolds chitosan neural regeneration 030217 neurology & neurosurgery Biomedical engineering Research Article |
| Zdroj: | Neural Regeneration Research, Vol 12, Iss 4, Pp 614-622 (2017) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Conventional fabrication methods lack the ability to control both macro- and micro-structures of generated scaffolds. Three-dimensional printing is a solid free-form fabrication method that provides novel ways to create customized scaffolds with high precision and accuracy. In this study, an electrically controlled cortical impactor was used to induce randomized brain tissue defects. The overall shape of scaffolds was designed using rat-specific anatomical data obtained from magnetic resonance imaging, and the internal structure was created by computer-aided design. As the result of limitations arising from insufficient resolution of the manufacturing process, we magnified the size of the cavity model prototype five-fold to successfully fabricate customized collagen-chitosan scaffolds using three-dimensional printing. Results demonstrated that scaffolds have three-dimensional porous structures, high porosity, highly specific surface areas, pore connectivity and good internal characteristics. Neural stem cells co-cultured with scaffolds showed good viability, indicating good biocompatibility and biodegradability. This technique may be a promising new strategy for regenerating complex damaged brain tissues, and helps pave the way toward personalized medicine. |
| Databáze: | OpenAIRE |
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