Pathogenesis of oral type I feline infectious peritonitis virus (FIPV) infection: Antibody-dependent enhancement infection of cats with type I FIPV via the oral route
| Autor: | Tomomi Takano, Tomoyoshi Doki, Tsutomu Hohdatsu, Shinji Yamada |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Feline coronavirus
040301 veterinary sciences medicine.disease_cause Antibodies Viral 0403 veterinary science Pathogenesis 03 medical and health sciences Virology oral infection medicine Oral route Animals Antibody-dependent enhancement feline infectious peritonitis Coronavirus Feline antibody-dependent enhancement feline coronavirus 030304 developmental biology Coronavirus 0303 health sciences CATS biology Full Paper General Veterinary business.industry 04 agricultural and veterinary sciences Feline infectious peritonitis biology.protein Cats Antibody business |
| Zdroj: | Journal of Veterinary Medical Science The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.18-0702 |
| Popis: | Feline infectious peritonitis virus (FIPV) causes a severe, immune-mediated disease called FIP in domestic and wild cats. It is unclear whether FIP transmits from cat to cat through the oral route of FIPV infection, and the reason for this includes that FIP is caused by oral inoculation with some FIPV strains (e.g., type II FIPV WSU 79-1146), but is not caused by other FIPV (e.g., type I FIPV KU-2 strain: FIPV-I KU-2). In this study, when cats passively immunized with anti-FIPV-I KU-2 antibodies were orally inoculated with FIPV-I KU-2, FIP was caused at a 50% probability, i.e., FIPV not causing FIP through oral infection caused FIP by inducing antibody-dependent enhancement. Many strains of type I FIPV do not cause FIP by inoculation through the oral route in cats. Based on the findings of this study, type I FIPV which orally infected cats may cause FIP depending on the condition. |
| Databáze: | OpenAIRE |
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