Serological Approaches for Trypanosoma cruzi Strain Typing
| Autor: | Guadalupe Romer, Leonel Esteban Bracco, Alejandro Daniel Ricci, Fernán Agüero, Virginia Balouz, Carlos A. Buscaglia |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Serotype Trypanosoma cruzi 030231 tropical medicine Computational biology Disease Article Serology Immunomics 03 medical and health sciences 0302 clinical medicine Species Specificity parasitic diseases Animals Humans Chagas Disease Serologic Tests Typing Genetic variability Genotyping biology biology.organism_classification 030104 developmental biology Infectious Diseases Parasitology |
| Zdroj: | Trends Parasitol |
| ISSN: | 1471-4922 |
| Popis: | Trypanosoma cruzi, the protozoan agent of Chagas' disease, displays a complex population structure made up of multiple strains showing a diverse ecoepidemiological distribution. Parasite genetic variability may be associated with disease outcome, hence stressing the need to develop methods for T. cruzi typing in vivo. Serological typing methods that exploit the presence of host antibodies raised against polymorphic parasite antigens emerge as an appealing approach to address this issue. These techniques are robust, simple, cost-effective, and are not curtailed by methodological/biological limitations intrinsic to available genotyping methods. Here, we critically assess the progress towards T. cruzi serotyping and discuss the opportunity provided by high-throughput immunomics to improve this field. |
| Databáze: | OpenAIRE |
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