Detection of spleen abscesses facilitates diagnosis of melioidosis in Malaysian children
| Autor: | Kamilah Manan, Mong-How Ooi, Rohani Ahmad, Teik-Beng Chuah, Yee-Chin Tan, Peter Sie-Teck Lau, Qairul Irwan Hamli, Su-Lin Chien, Yuwana Podin, Shi-Tying Chin, Anand Mohan, Lee-See Tan |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Tuberculosis Melioidosis Spleen abscess 030106 microbiology lcsh:Infectious and parasitic diseases Serology 03 medical and health sciences 0302 clinical medicine Internal medicine Case fatality rate medicine Humans lcsh:RC109-216 030212 general & internal medicine Child Children Retrospective Studies Splenic Diseases Ultrasonography medicine.diagnostic_test business.industry Malaysia General Medicine medicine.disease Occult Liver abscess Infectious Diseases Child Preschool Abdominal ultrasonography Etiology Intraabdominal Infections Female business |
| Zdroj: | International Journal of Infectious Diseases, Vol 98, Iss, Pp 59-66 (2020) |
| ISSN: | 1201-9712 |
| Popis: | Objectives Melioidosis is associated with extremely high case fatality ratios. The aim of this study was to determine whether detection of abdominal visceral abscesses can facilitate diagnosis of melioidosis in children. Methods We conducted a retrospective analysis of all children who had liver and/or spleen abscesses on abdominal ultrasonography admitted to Bintulu Hospital in Sarawak, Malaysia, from January 2014 until December 2018. Results Fifty-three children had liver and/or spleen abscesses. Spleen abscesses were present in 48 (91%) cases; liver abscesses in 15 (28%). Melioidosis was confirmed by culture in 9 (17%) children; small occult splenic abscesses were present in all cases. In 78% of these cases, the lesions were detected before any positive culture (or serology) results were available. Four (8%) children had bacteriologically-confirmed tuberculosis. Two (4%) had Staphylococcus aureus infection. Of the remaining 38 (72%) culture-negative cases, 36 (95%) had clinical and imaging characteristics similar to that of children with culture-confirmed melioidosis and improved with empirical melioidosis antibiotic therapy. Conclusions A large number of children in Bintulu Hospital in Sarawak, Malaysia, were found to have spleen abscesses. Melioidosis was the most common etiology identified in these children. Abdominal ultrasonography is extremely useful in facilitating the diagnosis of pediatric melioidosis. |
| Databáze: | OpenAIRE |
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