Targeting PVR (CD155) and its receptors in anti-tumor therapy
| Autor: | Paola Kucan Brlic, Stipan Jonjić, Guy Cinamon, Ofer Mandelboim, Tihana Lenac Rovis, Pini Tsukerman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
tumor TIGIT medicine.medical_treatment Immunology PVR Review Article Immunotherapy Adoptive Cell therapy 03 medical and health sciences checkpoint 0302 clinical medicine Neoplasms Animals Humans Immunology and Allergy Medicine CD155 Receptors Immunologic Receptor Tumor marker Clinical Trials as Topic Tumor microenvironment poliovirus biology business.industry BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences Immunotherapy eye diseases Oncolytic virus 030104 developmental biology Infectious Diseases biology.protein Cancer research Receptors Virus immunotherapy BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti business Poliovirus Receptor Protein Binding 030215 immunology |
| Zdroj: | Cellular and Molecular Immunology Volume 16 Issue 1 |
| ISSN: | 2042-0226 1672-7681 |
| DOI: | 10.1038/s41423-018-0168-y |
| Popis: | Poliovirus receptor (PVR, CD155) has recently been gaining scientific interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions. In contrast to healthy tissues, PVR is expressed at high levels in several human malignancies and seems to have protumorigenic and therapeutically attractive properties that are currently being investigated in the field of recombinant oncolytic virotherapy. More intriguingly, PVR participates in a considerable number of immunoregulatory functions through its interactions with activating and inhibitory immune cell receptors. These functions are often modified in the tumor microenvironment, contributing to tumor immunosuppression. Indeed, increasing evidence supports the rationale for developing strategies targeting these interactions, either in terms of checkpoint therapy (i.e., targeting inhibitory receptors) or in adoptive cell therapy, which targets PVR as a tumor marker. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink