Tumor necrosis factor alpha is not a pathogenic determinant in acute lethal encephalitis induced by a highly neurovirulent strain of mouse hepatitis virus
| Autor: | Kazuya Shirato, Masuhiro Takata, Eiichi Momotani, Takahide Taniguchi, Kenji Sekikawa |
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| Rok vydání: | 2007 |
| Předmět: |
animal diseases
viruses Apoptosis Proinflammatory cytokine Pathogenesis Mice Mouse hepatitis virus Virology medicine Animals Encephalitis Viral Murine hepatitis virus biology Tumor Necrosis Factor-alpha virus diseases Gene targeting General Medicine medicine.disease biology.organism_classification Mice Inbred C57BL nervous system Viral replication Gene Targeting Immunology Tumor necrosis factor alpha Coronavirus Infections Encephalitis |
| Zdroj: | Archives of Virology. 153:549-553 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/s00705-007-0006-5 |
| Popis: | To investigate the role of tumor necrosis factor alpha (TNFalpha) in the pathogenesis of acute viral encephalitis, TNFalpha-deficient mice were infected with a highly neurovirulent strain of mouse hepatitis virus, JHM, and compared with JHM-infected C57BL/6 mice as controls. All the JHM-infected mice had succumbed to infection by 6 days postinfection. The virus replication kinetics, histopathological changes and mRNA expression levels of proinflammatory cytokines in the brain did not differ between TNFalpha-deficient and control C57BL/6 mice. These results suggest that TNFalpha is not a pathogenic determinant in JHM-induced acute lethal encephalitis. |
| Databáze: | OpenAIRE |
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