Seizure-inducing paradoxical reaction to antiepileptic drugs
| Autor: | Elisabeth Korn-Merker, Ulrich Bettendorf, Peter Borusiak, Hans Erich Boenigk, Michael Karenfort |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Phenytoin
medicine.medical_treatment Clonazepam Epilepsy Developmental Neuroscience Convulsion Humans Medicine business.industry musculoskeletal neural and ocular physiology Infant Paradoxical reaction Electroencephalography General Medicine medicine.disease Discontinuation Anticonvulsant Anesthesia Pediatrics Perinatology and Child Health Anticonvulsants Drug Therapy Combination Female Neurology (clinical) medicine.symptom business Primidone medicine.drug |
| Zdroj: | Brain and Development. 22:243-245 |
| ISSN: | 0387-7604 |
| DOI: | 10.1016/s0387-7604(00)00122-4 |
| Popis: | We report on an 18-month-old girl with a seizure frequency of five/day, receiving an antiepileptic polytherapy consisting of primidone, clonazepam and phenytoin. Following discontinuation of clonazepam and primidone, the patient has been seizure-free under monotherapy for 2 years and shows marked developmental progress. Possible mechanisms of this paradoxical effect of antiepileptic drugs and the implications for antiepileptic therapy are discussed. |
| Databáze: | OpenAIRE |
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