Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates
| Autor: | Evgenia Roussinova, Grégoire Courtine, Florian Fallegger, Andrew Bogaard, Elena Losanno, Simon Borgognon, Jocelyne Bloch, Ilaria Scarpato, Eric Schmidlin, Stéphanie P. Lacour, Maude Delacombaz, Silvestro Micera, Marion Badi, Paul Čvančara, Thomas Stieglitz, David K. Su, Sophie Wurth, Eric M. Rouiller, Marco Capogrosso |
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| Rok vydání: | 2021 |
| Předmět: |
Primates
spastic paresis medicine.medical_specialty restoration grasp Movement electrical-stimulation Peripheral nerve stimulation Stimulation tetraplegia system implanted neuroprosthesis h-reflexes Hand movements Physical medicine and rehabilitation Paralysis Medicine Animals Peripheral Nerves Tetraplegia business.industry General Medicine medicine.disease Hand Spastic paresis motor Electric Stimulation frequency medicine.symptom business |
| Zdroj: | Science translational medicine. 13(617) |
| ISSN: | 1946-6242 |
| Popis: | Restoring dexterous hand control is critical for people with paralysis. Approaches based on surface or intramuscular stimulation provide limited finger control, generate insufficient force to recover functional movements, and require numerous electrodes. Here, we show that intrafascicular peripheral electrodes could produce functional grasps and sustained forces in three monkeys. We designed an intrafascicular implantable electrode targeting the motor fibers of the median and radial nerves. Our interface selectively and reliably activated extrinsic and intrinsic hand muscles, generating multiple functional grips, hand opening, and sustained contraction forces for up to 2 months. We extended those results to a behaving monkey with transient hand paralysis and used intracortical signals to control simple stimulation protocols that enabled this animal to perform a functional grasping task. Our findings show that just two intrafascicular electrodes can generate a rich portfolio of dexterous and functional hand movements with important implications for clinical applicability. |
| Databáze: | OpenAIRE |
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