CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity
| Autor: | Charles R. Rinaldo, Pawel Kalinski, Russell D. Salter, Velpandi Ayyavoo, Aarika L. Yates, Simon C. Watkins, Ronald J Fecek, Robbie B. Mailliard, Colleen R. Zaccard |
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| Rok vydání: | 2014 |
| Předmět: |
Cellular immunity
Cell signaling T cell Immunology CD40 Ligand Cell Communication Lymphocyte Activation Article Immune system Antigen T-Lymphocyte Subsets medicine Immunology and Allergy Humans Cells Cultured CD40 biology Biological Transport Dendritic Cells T-Lymphocytes Helper-Inducer Coculture Techniques Cell biology medicine.anatomical_structure biology.protein Signal transduction Inflammation Mediators Function (biology) Signal Transduction |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 194(3) |
| ISSN: | 1550-6606 |
| Popis: | The ability of dendritic cells (DC) to mediate CD4+ T cell help for cellular immunity is guided by instructive signals received during DC maturation, as well as the resulting pattern of DC responsiveness to the Th signal, CD40L. Furthermore, the professional transfer of antigenic information from migratory DC to lymph node–residing DC is critical for the effective induction of cellular immune responses. In this study we report that, in addition to their enhanced IL-12p70 producing capacity, human DC matured in the presence of inflammatory mediators of type 1 immunity are uniquely programmed to form networks of tunneling nanotube-like structures in response to CD40L-expressing Th cells or rCD40L. This immunologic process of DC reticulation facilitates intercellular trafficking of endosome-associated vesicles and Ag, but also pathogens such HIV-1, and is regulated by the opposing roles of IFN-γ and IL-4. The initiation of DC reticulation represents a novel helper function of CD40L and a superior mechanism of intercellular communication possessed by type 1 polarized DC, as well as a target for exploitation by pathogens to enhance direct cell-to-cell spread. |
| Databáze: | OpenAIRE |
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