Survival and Quality of Life Benefit after Endoscopic Management of Malignant Central Airway Obstruction
| Autor: | Charalampos Dimitropoulos, Nikos Koufos, Grigoris Stratakos, Spyros Zakynthinos, Vasiliki Gerovasili, Filippos T. Filippidis, Sofia Antiopi Gennimata, Nikos Koulouris, Athanasia Pataka, Konstantinos N. Syrigos, Athanasios Zissimopoulos, Ioannis Giozos, Paul Zarogoulidis |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry medicine.medical_treatment 030204 cardiovascular system & hematology Endoscopic management Malignancy medicine.disease Surgery Radiation therapy lung cancer 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Oncology Quality of life medicine Central airway In patient quality of life Lung cancer business intervention Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Background: Although interventional management of malignant central airway obstruction (mCAO) is well established, its impact on survival and quality of life (QoL) has not been extensively studied. Aim: We prospectively assessed survival, QoL and dyspnea (using validated EORTC questionnaire) in patients with mCAO 1 day before interventional bronchoscopy, 1 week after and every following month, in comparison to patients who declined this approach. Material/Patients/Methods: 36 patients underwent extensive interventional bronchoscopic management as indicated, whereas 12 declined. All patients received full chemotherapy and radiotherapy as indicated. Patients of the 2 groups were matched for age, comorbidities, type of malignancy and level of obstruction. Follow up time was 8.0±8.7 (range 1-38) months. Results: Mean survival for intervention and control group was 10±9 and 4±3 months respectively (p=0.04). QoL improved significantly in intervention group patients up to the 6th month (p |
| Databáze: | OpenAIRE |
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