No clear effect of postoperative radiotherapy on survival of breast cancer patients with one to three positive nodes: a population-based study
| Autor: | C. Chamalidou, Helena Fohlin, Erik Holmberg, Bo Nordenskjöld, Per Albertsson, Lars-Gunnar Arnesson, Per Karlsson, Zakaria Einbeigi, Anna Nordenskjöld |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Population Postoperative radiotherapy Breast Neoplasms Breast cancer Catchment Area Health Residence Characteristics Risk Factors Breast-conserving surgery Humans Medicine Registries education Adverse effect Mastectomy Aged Sweden education.field_of_study Relative survival business.industry Hematology Middle Aged medicine.disease Survival Analysis Surgery Radiation therapy Treatment Outcome Oncology Chemotherapy Adjuvant Lymphatic Metastasis Female Radiotherapy Adjuvant Lymph business Mammography |
| Zdroj: | Annals of Oncology. 26:1149-1154 |
| ISSN: | 0923-7534 |
| Popis: | Background In published radiotherapy trials, the failure rate in the control arm among patients with one to three positive nodes is high compared with that seen with modern adjuvant treatments. Therefore, the generalizability of the results has been questioned. The aim of the present study was to compare relative survival in breast cancer patients between two Swedish regions with screening mammography programs and adjuvant treatment guidelines similar with the exception of the indication of radiotherapy for patients with one to three positive nodes. Patients and methods Between 1989 and 2006, breast cancer patients were managed very similarly in the west and southeast regions, except for indication for postoperative radiotherapy. In patients with one to three positive nodes, postmastectomy radiotherapy was generally given in the southeast region (89% of all cases) and generally not given in the west region (15% of all cases). For patients with one to three positive nodes who underwent breast-conserving surgery, patients in the west region had breast radiotherapy only, while patients in the southeast region had both breast and lymph nodes irradiated. Results The 10-year relative survival for patients with one to three positive lymph nodes was 78% in the west region and 77% in the southeast region (P = 0.12). Separate analyses depending on type of surgery, as well as number of examined nodes, also revealed similar relative survival. Conclusion Locoregional postoperative radiotherapy has well-known side-effects, but in this population-based study, there was little or no influence of this type of radiotherapy on survival when one to three lymph nodes were involved. |
| Databáze: | OpenAIRE |
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