Fibromuscular dysplasia – results of a multicentre study in Flanders

Autor: Marie De Groote, Bert Callewaert, Patricia Van der Niepen, Jean-Marie Billiouw, Tine De Backer, Jan Donck, An S. De Vriese, Frank Vermassen, Dimitri Hemelsoet
Přispěvatelé: Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology
Rok vydání: 2017
Předmět:
Adult
Carotid Artery Diseases
Male
Pediatrics
medicine.medical_specialty
Cross-sectional study
medical imaging
Disease
Fibromuscular dysplasia
030204 cardiovascular system & hematology
cerebrovascular
renovascular
03 medical and health sciences
0302 clinical medicine
Aneurysm
Belgium
Predictive Value of Tests
Epidemiology
Prevalence
medicine
Fibromuscular Dysplasia
Humans
Registries
cardiovascular diseases
Sex Distribution
Aged
Retrospective Studies
Incidental Findings
Vascular disease
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
Embolization
Therapeutic
Cerebrovascular Disorders
Cross-Sectional Studies
Treatment Outcome
Predictive value of tests
cardiovascular system
Female
Cardiology and Cardiovascular Medicine
business
Angioplasty
Balloon
030217 neurology & neurosurgery
Zdroj: Vasa. 46:211-218
ISSN: 1664-2872
0301-1526
Popis: Abstract. Background: Fibromuscular dysplasia (FMD) is an idiopathic, non-inflammatory, non-atherosclerotic vascular disease, resulting in focal narrowing of small and medium-sized arteries. Systematic recording of clinical data in central databases as in the US and France provided new insights into FMD. The main objectives of this multicentre study were to explore the epidemiology, pattern of vascular involvement, clinical manifestations, and management of FMD patients in Flanders. Patients and methods: Multicentre, retrospective registry of patients diagnosed with FMD based on medical imaging. Results: Hundred-twenty-three FMD patients (83.7 % female) were included. Mean age at FMD diagnosis was 57.3 years (SD 15.8). More than half of patients (59.5 %) were hypertensive at the time of diagnosis. Neurological complaints such as headache (26.4 %) and dizziness (23.1 %) were also frequently reported. FMD was discovered incidentally in 10 patients (8.3 %). Nearly one quarter (22.8 %) of patients experienced a cerebrovascular event. Aneurysms were found in one-fifth (20.3 %) of patients and 11.4 % had an arterial dissection. FMD affected most frequently the renal (85.3 %), carotid (74.7 %), and vertebral (39.8 %) arteries. Renovascular FMD was more prevalent in men, whereas cerebrovascular FMD was more frequent in women. Multiple affected sites were documented in 25 of 61 (41.0 %) patients, having two or more vascular beds imaged. Digital subtraction angiography was most frequently used for detecting FMD. One third (32.9 %) of patients received an interventional treatment, mainly patients with renovascular FMD (32.8 % underwent percutaneous transluminal angioplasty) and patients with an intracranial carotid aneurysm (36.4 % were treated by means of coiling). Conclusions: Although differences existed, results of the Flemish registry were broadly in line with the US and French registries. Patient databases help to learn more about the natural history, progression, and management of FMD, based on real life clinical evidence.
Databáze: OpenAIRE
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