Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis-4 score and aspartate aminotransferase-platelet ratio index
| Autor: | Jacqueline A. Bachofner, Joachim C. Mertens, Burkhardt Seifert, Benedetta Terziroli Beretta-Piccoli, Patrizia Künzler, Lorenzo Magenta, Arne Kröger, Piero V. Valli, Adriana Baserga, David Semela, Dominique L Braun, Beat Müllhaupt, Anja Moncsek, Jan Fehr, Irina Bergamin |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Platelets
Liver Cirrhosis Male medicine.medical_specialty Sustained Virologic Response Rapid regression Concordance Hepatitis C virus Hepacivirus medicine.disease_cause Antiviral Agents Severity of Illness Index Gastroenterology 03 medical and health sciences 0302 clinical medicine Chronic hepatitis Fibrosis Internal medicine medicine Humans Platelet Aspartate Aminotransferases Retrospective Studies Hepatology business.industry Ultrasound Hepatitis C Chronic Middle Aged medicine.disease Surgery Liver 030220 oncology & carcinogenesis Disease Progression Elasticity Imaging Techniques Drug Therapy Combination Female 030211 gastroenterology & hepatology business Transient elastography Biomarkers Switzerland |
| Zdroj: | Liver International. 37:369-376 |
| ISSN: | 1478-3223 |
| Popis: | BACKGROUND Novel direct antiviral agents (DAA) targeting hepatitis C virus (HCV) have revolutionized the treatment of chronic hepatitis C infection (CHC). Rates of sustained virological response (SVR) to treatment have drastically improved since introduction of DAA. Transient Elastography (TE) is an ultrasound based, non-invasive technique to assess liver stiffness (LS). We examined the changes in TE values and fibrosis scores FIB-4 and APRI after DAA treatment of CHC. METHODS 549 patients who received a DAA based treatment for CHC were screened and 392 were included. TE values recorded prior to therapy and within 18 months after therapy were evaluated. In addition, FIB-4 and APRI scores were calculated and histological results were recorded if available. RESULTS Median TE prior to DAA treatment was 12.65 kPa (IQR 9.45 - 19.2 kPa) and decreased to 8.55 kPa (IQR 5.93 - 15.25) post-treatment. This finding is statistically significant (p < 0.001) and equals a TE regression of 32.41% after DAA treatment. Median FIB-4 and APRI values significantly decreased from 2.54 (IQR 1.65-4.43) and 1.10 (IQR 0.65-2.43) to 1.80 (IQR 1.23-2.84, p < 0.001) and 0.43 (IQR 0.3-0.79, p < 0.001), respectively. CONCLUSION Patients with SVR after DAA therapy showed significant regression of TE values. Rapid decrease of TE was in concordance with regression of validated fibrosis scores FIB-4 and APRI. It remains to be examined whether this indicates a regression of fibrosis or merely resolution of chronic liver inflammation with subsequent improvement of TE values and laboratory parameters. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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