Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer
| Autor: | Kevin A. Kowalski, Lisa Flowers, Sulma I. Mohammed, Jun Xie, Krystal Madden, Ritu Salani, Sanjay Logan, Ira R. Horowitz |
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| Rok vydání: | 2008 |
| Předmět: |
Proteomics
Pathology medicine.medical_specialty Curcumin Clinical Biochemistry Uterine Cervical Neoplasms Dinoprostone chemistry.chemical_compound Medicine Humans Cervix Cell Proliferation Cervical cancer business.industry Carcinoma in situ Cancer Cell Biology Cell cycle medicine.disease Antineoplastic Agents Phytogenic medicine.anatomical_structure chemistry Cyclooxygenase 2 Cancer research Immunohistochemistry Adenocarcinoma Female business Metabolic Networks and Pathways HeLa Cells |
| Zdroj: | Prostaglandins, leukotrienes, and essential fatty acids. 80(1) |
| ISSN: | 0952-3278 |
| Popis: | Cervical cancer is the second leading cause of cancer death for women in the world. A potential target for preventing and treating cervical cancer is cyclooxygenase-2 (cox-2). Curcumin is an anti-inflammatory agent that is known to have anti-cox-2 activity. In this study we examined the expression of cox-2 in cervical cancer and its precursors by immunohistochemistry. The effect of curcumin in inhibiting cervical cancer cells was determined via 2-dimensional gel electrophoresis, data analysis, and ingenuity pathway analysis. No significant differences in the expression of cox-2 in squamous cell carcinoma, and carcinoma in situ were observed. However, there was a statistically significant difference in the expression of cox-2 in adenocarcinoma in comparison to normal (p value=0.01) and squamous cell carcinoma (p value=0.02) tissues. Proteins associated with cancer and cell cycle were significantly altered in cultured cells. Curcumin may have antitumor effect in cervical cancer. |
| Databáze: | OpenAIRE |
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