Forced Degradation Studies of Aloe Emodin and Emodin by HPTLC
| Autor: | Aruna P. Jadhav, Vilasrao J. Kadam, Sindhu Narayanan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
Chromatography Traditional medicine medicine.medical_treatment Short Communication Pharmaceutical Science Anthraquinones aloe emodin forced degradation Aloe emodin high-performance thin layer chromatography emodin Hydrolysis chemistry.chemical_compound chemistry Forced degradation medicine Acid hydrolysis High performance thin layer chromatography Emodin medicine.drug |
| Zdroj: | Indian Journal of Pharmaceutical Sciences |
| ISSN: | 0250-474X |
| Popis: | Anthraquinones are natural phenolic compounds, which are reported to act as anti-aging, anti-inflammatory, antioxidant, anti-cancer, laxative and antitumor agents. They are abudant in plants like candle bush, aloes, cascara bark and rhubarb. The present work was to observe the effect of different forced degradation conditions by high-performance thin layer chromatography on potential markers i.e. aloe emodin and emodin. Both aloe emodin and emodin were subjected to various forced degradation studies such as oxidation, acid and alkaline hydrolysis, photolysis, hydrolytic and thermal degradation. Aloe emodin, was more susceptible to acid hydrolysis and degradation was found to a lesser extent under thermal degradation whereas significant degradation was observed under acid hydrolysis, lesser extent was observed under alkali hydrolysis for emodin. Forced degradation studies on aloe emodin and emodin gives information about its storage and intrinsic stability conditions considering the advanced pharmaceutical aspects of formulation. |
| Databáze: | OpenAIRE |
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