Alpha-lipoic acid and vitamin B complex slow down the changes in mice diabetic cardiomyopathy
| Autor: | Georgică Costinel Târtea, Diana R Florescu, Alexandru Radu Mihailovici, Octavian Istrătoaie, Ionuţ Donoiu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Embryology medicine.medical_specialty Diabetic Cardiomyopathies Alpha-Lipoic Acid medicine.medical_treatment Intraperitoneal injection Vitamin b complex 030209 endocrinology & metabolism 030204 cardiovascular system & hematology streptozotocin Pathology and Forensic Medicine 03 medical and health sciences Mice 0302 clinical medicine Diabetes mellitus Internal medicine Diabetic cardiomyopathy medicine diabetic cardiomyopathy Animals Original Paper Ejection fraction Thioctic Acid business.industry Cell Biology General Medicine medicine.disease Streptozotocin Endocrinology diabetes mellitus Vitamin B Complex Myocardial fibrosis Female business Developmental Biology medicine.drug |
| Zdroj: | Romanian Journal of Morphology and Embryology |
| ISSN: | 2066-8279 1220-0522 |
| Popis: | Aim The aim of our study was to assess histologically and by cardiac ultrasound the effects of alpha-lipoic acid (ALA) and vitamin B complex, as pathogenic therapies, in diabetic cardiomyopathy (DCM) in mice. Materials and methods We performed an experimental animal study, in which we analyzed from a structural and functional point of view the changes produced in DCM. To produce DCM, we induced diabetes mellitus (DM) in C57BL∕6 mice by intraperitoneal injection of a single 150 mg∕kg body weight dose of streptozotocin (STZ). We formed a sham group (animals without DM), a control group (animals with DM but without treatment, DM_Control) and a group of animals with DM that were treated with ALA and vitamin B complex (DM_Treated). Results At six weeks after STZ administration, there was no decrease in left ventricular ejection fraction (LVEF) in the sham group, while in the control group there was a significant decrease in LVEF, about 43.75±3.37%, compared to the group that received treatment with ALA and vitamin B complex, in which LVEF decreased to 49.6±5.02% (p=0.0432). Also, the degree of interstitial myocardial fibrosis was higher in animals with DM compared to animals without DM, but the applied therapeutic protocol considerably improved the accumulation of interstitial collagen. The same observation was maintained regarding the evaluation of polysaccharide deposits. Conclusions We can say that the administration of ALA and vitamin B complex in mice with STZ-induced DM, improves the degree of myocardial fibrosis, the accumulation of polysaccharides, and prevents severe deterioration of systolic and diastolic function of the heart. |
| Databáze: | OpenAIRE |
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