The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis
| Autor: | V V Zdor, E V Markelova |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment General Medicine RC648-665 Anti-thyroid autoantibodies cytokines Diseases of the endocrine glands. Clinical endocrinology Proinflammatory cytokine thiamazole Endocrinology Blood serum Immune system Cytokine Internal medicine Immunology medicine business autoimmune thyrotoxicosis Autoimmune thyrotoxicosis |
| Zdroj: | Клиническая и экспериментальная тиреоидология, Vol 9, Iss 4, Pp 27-30 (2013) |
| ISSN: | 2310-3787 1995-5472 |
| Popis: | One of the key, as well as regulatory, roles in immune response is given to the system of cytokines. The change in the content of serum opposite’s cytokines in GD is dynamic. The beginning of autoimmune thyrotoxicosis shows the largest amounts of cytokines - IL-1α and IL-1β, IFN-γ, IL-17, TGF-β and IL-10. It has been proved that there is a direct correlation dependence of the degree of the severity of the autoimmune thyrotoxicosis on the content of proinflammatory (IL-1α and IL-1β, IFN-γ, IL-17) and anti-inflammatory TGF-β, IL-10 cytokines in the patient’s blood serum, as well as on the production of anti-receptive thyroid autoantibodies. The benefits of study indexed that, long-term Thiamazole treatment in generally accepted standard doses demonstrates significant reduction of cytokine volume. It has also made it possible to work out the algorithm of the development of autoimmune thyrotoxicosis recurrence. |
| Databáze: | OpenAIRE |
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