SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19
| Autor: | Riccardo Giorgino, Giuseppe De Blasio, Maurizio Turiel, Alfonso Ielasi, Fabio Pino, Mauro Porta, Matteo Briguglio, Alberto R. Bona, Giuseppe De Angelis, Tiziano Crespi, Marco Mazzocchi, Paolo Perazzo, Francesca Zuffada |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology coronavirus 030204 cardiovascular system & hematology medicine.disease_cause Pericardial effusion lcsh:Physiology 03 medical and health sciences 0302 clinical medicine quality of health care Physiology (medical) Case fatality rate medicine host-pathogen interactions infections 030212 general & internal medicine Intensive care medicine Stroke Coronavirus Ejection fraction lcsh:QP1-981 SARS-CoV-2 business.industry COVID-19 Sequela medicine.disease Pathophysiology virulence Malnutrition Perspective cardiovascular system business |
| Zdroj: | Frontiers in Physiology, Vol 11 (2020) Frontiers in Physiology |
| ISSN: | 1664-042X |
| DOI: | 10.3389/fphys.2020.571367 |
| Popis: | The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the high fatality rate of coronavirus disease 2019 (COVID-19) have been putting a strain on the world since December 2019. Infected individuals exhibit unpredictable symptoms that tend to worsen if age is advanced, a state of malnutrition persists, or if cardiovascular comorbidities are present. Once transmitted, the virus affects the lungs and in predisposed individuals can elicit a sequela of fatal cardiovascular consequences. We aim to present the pathophysiology of COVID-19, emphasizing the major cellular and clinical manifestations from a cardiological perspective. As a roaming viral particle or more likely via the Trojan horse route, SARS-CoV-2 can access different parts of the body. Cardiovascular features of COVID-19 can count myocardial injuries, vasculitis-like syndromes, and atherothrombotic manifestations. Deviations in the normal electrocardiogram pattern could hide pericardial effusion or cardiac inflammation, and dispersed microthrombi can cause ischemic damages, stroke, or even medullary reflex dysfunctions. Tailored treatment for reduced ejection fraction, arrhythmias, coronary syndromes, macrothrombosis and microthrombosis, and autonomic dysfunctions is mandatory. Confidently, evidence-based therapies for this multifaceted nevertheless purely cardiological COVID-19 will emerge after the global assessment of different approaches. |
| Databáze: | OpenAIRE |
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