Merkel Cell Carcinoma (Primary Neuroendocrine Carcinoma of Skin) Mimicking Basal Cell Carcinoma With Review of Different Histopathologic Features
| Autor: | Farah Succaria, Jag Bhawan, Arash Radfar |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Pathology medicine.medical_specialty Skin Neoplasms Eccrine carcinoma Dermatology Malignancy Pathology and Forensic Medicine Diagnosis Differential Cytokeratin Internal medicine Biomarkers Tumor medicine Carcinoma Humans Basal cell carcinoma Shave biopsy Aged 80 and over medicine.diagnostic_test biology Merkel cell carcinoma business.industry food and beverages General Medicine medicine.disease Immunohistochemistry Carcinoma Merkel Cell Carcinoma Basal Cell Synaptophysin biology.protein Female business |
| Zdroj: | The American Journal of Dermatopathology. 36:160-166 |
| ISSN: | 0193-1091 |
| Popis: | Merkel cell carcinoma (MCC) is a rare but highly aggressive malignancy, which often has typical histopathologic and immunohistochemical (IHC) features. Sometimes the diagnosis is missed because of atypical histological or aberrant IHC findings. A case of MCC that showed irregular lobules of basaloid cells with keratotic areas on the initial shave biopsy is being reported. IHC showed positive staining for high-molecular weight cytokeratin but negative staining for cytokeratin 20, findings consistent with basal cell carcinoma. Subsequent excision specimen showed histopathologic features more typical of MCC. IHC still was negative for cytokeratin 20 but positive for synaptophysin. Review of the literature shows other examples of MCC with basal cell carcinoma-like features. Various other histopathologic differentiations of MCC include those that demonstrate squamous cell and eccrine carcinoma features and those that show melanocytic, lymphomatous, sarcomatous, muscular, and atypical fibroxanthoma-like features. Different histopathologic patterns and mimics of MCC are reviewed to help prevent dermatopathologists from misdiagnosing this aggressive tumor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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