The pentagastrin test in the diagnosis of the carcinoid syndrome
| Autor: | Dahlström A, K Oberg, Jaffe Bm, O. Nilsson, Ahlman H, K. O. Grönstad |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Ketanserin Time Factors Provocation test Substance P Carcinoid Tumor Gastroenterology Basal (phylogenetics) chemistry.chemical_compound Piperidines Internal medicine Medicine Humans Receptor Gastrointestinal Neoplasms Malignant Carcinoid Syndrome Pharmacology business.industry Hydroxyindoleacetic Acid medicine.disease Pentagastrin chemistry Receptors Serotonin Female Serotonin Serotonin Antagonists Cardiology and Cardiovascular Medicine business Carcinoid syndrome medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 7 |
| ISSN: | 0160-2446 |
| Popis: | Serotonin (5-HT) and substance P (SP) were assayed in peripheral blood in patients with known midgut carcinoids and hepatic metastases. All patients had supranormal basal levels of 5-HT and SP. The clinical and hormonal response was evaluated by two provocation tests, pentagastrin (PG) injection or calcium infusion. Pentagastrin caused flushing and gastrointestinal symptoms and elevated levels of circulating 5-HT, but not of SP. Pretreatment with a 5-HT2 receptor blocking agent (ketanserin) alleviated gastrointestinal symptoms but had no influence on either 5-HT release or PG-induced flushing. Calcium infusion induced carcinoid symptoms in only two of six patients, which were associated with elevated 5-HT levels (whereas elevated SP levels were seen in only one patient). We conclude that 5-HT is important for the development of gastrointestinal symptoms but not of flushing. Ketanserin may alleviate gastrointestinal symptoms but does not influence PG-induced release of 5-HT. Substance P and 5-HT do not seem to share a common release mechanism. It appears that PG testing is superior to calcium infusion as a provocative test in patients with the carcinoid syndrome. |
| Databáze: | OpenAIRE |
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