Neuroinflammation PET Imaging: Current Opinion and Future Directions
| Autor: | Mackenzie L. Carlson, Isaac M. Jackson, Michelle L. James, Poorva Jain, Anoushka Rao, Aisling Chaney |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nervous System Focus on Molecular Imaging 03 medical and health sciences 0302 clinical medicine Translocator protein Animals Humans Medicine Radiology Nuclear Medicine and imaging Clinical imaging Neuroinflammation Inflammation biology Data linking business.industry Pet imaging 030104 developmental biology Positron-Emission Tomography biology.protein Biomarker (medicine) Molecular imaging business Neuroscience Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | J Nucl Med |
| ISSN: | 2159-662X 0161-5505 |
| Popis: | Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is yet to be fully understood. PET imaging enables investigation, quantification, and tracking of different neuroinflammation biomarkers in living subjects longitudinally. One such biomarker that has been imaged extensively using PET is translocator protein 18 kDa (TSPO). Although imaging TSPO has yielded valuable clinical data linking neuroinflammation to various neurodegenerative diseases, considerable limitations of TSPO PET have prompted identification of other more cell-specific and functionally relevant biomarkers. This review analyzes the clinical potential of available and emerging PET biomarkers of innate and adaptive immune responses, with mention of exciting future directions for the field. |
| Databáze: | OpenAIRE |
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