Breast Cancer Profile among Patients with a History of Chemoprevention
| Autor: | Sarah Pivo, Deborah Axelrod, Jennifer Chun, Shira Schwartz, Amber A. Guth, Ana Paula Refinetti, Freya Schnabel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Article Subject business.industry Disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis Internal medicine medicine Pharmacology (medical) 030212 general & internal medicine Stage (cooking) business Research Article |
| Zdroj: | International Journal of Breast Cancer, Vol 2016 (2016) International Journal of Breast Cancer |
| ISSN: | 2090-3189 2090-3170 |
| Popis: | Purpose. This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease.Methods. Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided into primary (no history of breast cancer) and secondary (previous history of breast cancer) groups and compared to patients who never took chemoprevention.Results. 135 (6%) of 2430 women used chemoprevention. In the primary chemoprevention group (n= 18, 1%), 39% had completed >5 years of treatment, and fully 50% were on treatment at time of diagnosis. These patients were overwhelmingly diagnosed with ER/PR positive cancers (88%/65%) and were diagnosed with equal percentages (44%) of IDC and DCIS. 117 (87%) used secondary chemoprevention. Patients in this group were diagnosed with earlier stage disease and had lower rates of ER/PR-positivity (73%/65%) than the nonchemoprevention group (84%/72%). In the secondary group, 24% were on chemoprevention at time of diagnosis; 73% had completed >5 years of treatment.Conclusions. The majority of patients who used primary chemoprevention had not completed treatment prior to diagnosis, suggesting that the timing of initiation and compliance to prevention strategies are important in defining the pattern of disease in these patients. |
| Databáze: | OpenAIRE |
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