Cross-resistance to moxidectin and ivermectin on a meat sheep farm in France
| Autor: | C. Paraud, I. Pors, Anne Lespine, Jean-François Sutra, T. Marcotty, I. Devos |
|---|---|
| Přispěvatelé: | Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), VERDI-R&D, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Clinique Vétérinaire, Region Aquitaine Limousin Poitou-Charentes, SNGTV (Societe Nationale des Groupements Techniques Veterinaires, PARIS), Paraud, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Veterinary medicine Trichostrongylus animal diseases [SDV]Life Sciences [q-bio] Resistance Drug Resistance Trichostrongyloidiasis chemistry.chemical_compound Feces Ivermectin FECRT Intestine Small Anthelmintic Nematode Infections Cecum Abomasum Antinematodal Agents General Medicine Efficacy test 030108 mycology & parasitology Faecal egg count reduction test Teladorsagia circumcincta 3. Good health Moxidectin Female France Macrolides medicine.drug Sheep Diseases Biology Excretion 03 medical and health sciences Animal science parasitic diseases medicine Animals Parasite Egg Count Cross-resistance Sheep General Veterinary Trichostrongyloidea Pharmacokinetic parameters chemistry Parasitology Flock |
| Zdroj: | Veterinary Parasitology Veterinary Parasitology, Elsevier, 2016, 226, pp.88-92. ⟨10.1016/j.vetpar.2016.06.033⟩ Veterinary Parasitology (226), 88-92. (2016) |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/j.vetpar.2016.06.033⟩ |
| Popis: | International audience; Resistance to ivermectin and moxidectin was explored by a faecal egg count reduction test in two sheep flocks with suspected anthelmintic resistance. The FECRT confirmed one suspicion, with a mean percentage of reduction in egg excretion within the treated groups of 0% for ivermectin (CI 95%: -228 to 58) and 13% for moxidectin (CI 95%: -152 to 70). This was further explored by a controlled efficacy test. An experimental infection of 18 naive lambs was set up using infective larvae isolated from this flock (5000 L3/lamb). Compared to the control group, abomasal worm burdens (Teladorsagia circumcincta) were reduced by 90% [CI 95%: 81.5-94.8] and 85% [CI 95%: 72.4-92.2] after ivermectin (p < 0.05) and moxidectin (p < 0.05) treatment respectively. Again, compared to the control group, there was a reduction for intestinal strongyles (Trichostrongylus colubriformis) of 100% and 99% [CI 95%: 97.5-99.7] for ivermectin and moxidectin respectively. No difference was found between the efficacy of moxidectin and ivermectin. Pharmacokinetic values indicated that the strongyles were submitted to anthelmintic concentrations usually lethal to them. This trial demonstrated the first multiple resistance of ovine strongyles in France. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect