Effect of nodal status on clinical outcomes of triple-negative breast cancer: a population-based study using the SEER 18 database
| Autor: | Chuan Gui Song, Zhi Ming Shao, Yi-Zhou Jiang, Xiao Xiao Wang, Jun Jing Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty overall survival Triple Negative Breast Neoplasms computer.software_genre Malignancy 03 medical and health sciences 0302 clinical medicine Text mining Breast cancer Epidemiology medicine Humans Lymph node Triple-negative breast cancer Aged Proportional Hazards Models Database business.industry Proportional hazards model tumor size breast cancer-specific survival Middle Aged medicine.disease nodal status 030104 developmental biology medicine.anatomical_structure Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis triple-negative breast cancer Female Lymph Nodes Clinical Research Paper business computer SEER Program |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.9432 |
| Popis: | Triple-negative breast cancer (TNBC) is an aggressive malignancy with a poor prognosis. Data from the Surveillance, Epidemiology and End Results database (2010–2012) were used to identify 10,771 patients with TNBC, and we assessed the effects of lymph node (LN) status on breast cancer-specific survival (BCSS) and overall survival (OS). In our study, a Kaplan-Meier plot showed that LN-negative patients (N0) had better survival outcomes than LN-positive patients and that patients with ≥10 positive LNs (N3) exhibited the worst survival outcomes regardless of tumor size. A pairwise comparison showed no difference in survival outcomes among each group stratified by tumor size. Further, for LN-positive patients with a tumor size ≤2 cm (T1) or >5 cm (T3), there were similar outcomes between patients with one to three LNs (N1) and those with four to nine LNs (N2), whereas N1 patients experienced significantly better survival outcomes than N3 patients (P |
| Databáze: | OpenAIRE |
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