Bioactive nano-metal–organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria
| Autor: | Sanjeev K. Bhardwaj, Satish Kumar Pandey, Ki-Hyun Kim, Akash Deep, Neha Bhardwaj, Jyotsana Mehta |
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| Rok vydání: | 2018 |
| Předmět: |
Gram-negative bacteria
biology Chemistry medicine.drug_class Health Toxicology and Mutagenesis Antibiotics Kanamycin 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Toxicology medicine.disease_cause Antimicrobial biology.organism_classification 01 natural sciences Staphylococcus lentus 0104 chemical sciences Microbiology Multiple drug resistance Staphylococcus aureus Ampicillin medicine 0210 nano-technology medicine.drug |
| Zdroj: | Toxicology Research. 7:931-941 |
| ISSN: | 2045-4538 2045-452X |
| DOI: | 10.1039/c8tx00087e |
| Popis: | More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacies of three Zn-based nano metal–organic frameworks (nMOFs) – IRMOF-3, MOF-5, and Zn-BTC – were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli, Staphylococcus aureus, Staphylococcus lentus, and Listeria monocytogenes, the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-Based nMOFs can reduce the burden of the new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics. |
| Databáze: | OpenAIRE |
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