Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos

Autor: Victor Carlo Chevere, Marla Torres, Mariana C. Stern, Ebony Shah, Maria Gonzalez-Pons, Segundo Rodriguez-Quilichinni, Marcia Cruz-Correa, Julyann Pérez-Mayoral, Jose S. Reyes, Nicolas López, Marievelisse Soto-Salgado, Myrta I. Olivera, Rick A. Kittles, Luis Tous
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Colorectal cancer
Hispanic
lcsh:Medicine
0302 clinical medicine
Drug Discovery
0303 health sciences
education.field_of_study
Mortality rate
Incidence (epidemiology)
Hispanic or Latino
Middle Aged
3. Good health
African ancestry
030220 oncology & carcinogenesis
Molecular Medicine
Population study
Female
Primary Research
Colorectal Neoplasms
geographic locations
lcsh:QH426-470
Genetic genealogy
Population
Genetic ancestry
Ancestry-informative marker
White People
03 medical and health sciences
Genetics
medicine
Humans
Genetic Predisposition to Disease
Latinos
education
Molecular Biology
neoplasms
030304 developmental biology
Aged
business.industry
Puerto Rico
lcsh:R
Cancer
medicine.disease
Indians
Central American
Colorectal tumors
digestive system diseases
Black or African American
lcsh:Genetics
Case-Control Studies
business
Demography
Zdroj: Human Genomics, Vol 13, Iss 1, Pp 1-11 (2019)
Human Genomics
ISSN: 1479-7364
DOI: 10.1186/s40246-019-0196-4
Popis: Background Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporting the importance of studying this CRC health disparity. The genetic background of the Puerto Rican population is a mix of European, African, and Amerindian races, which may account, in part, for the differences observed in the CRC mortality rates among Puerto Ricans. The objective of the study was to assess the role of genetic ancestry in CRC risk and its association with clinicopathological features of CRC tumors in Puerto Ricans. Results We used a validated panel of 105 ancestry informative markers (AIMs) to estimate genetic ancestry in 406 Puerto Rican CRC cases and 425 Puerto Rican controls. We examined the association of genetic ancestry with CRC risk and tumor clinicopathological characteristics. Conclusions The mean ancestry proportions in the study population were 61% European, 21% African, and 18% Amerindian. No association was observed between genetic ancestry and risk of CRC. However, African ancestry was associated with an increased risk of developing rectal tumors (OR = 1.55, 95% CI 1.04–2.31). Additional studies are needed to fully elucidate the role of African ancestry in CRC carcinogenesis.
Databáze: OpenAIRE
Externí odkaz: