Addition of multimodal therapy to standard management of steady state sickle cell disease
| Autor: | Iheanyi Okpala, Uche Ololo, Charles Nonyelu, Ifeoma J Emodi, TU Nwagha, Ogechukwu Ugwu, Barth F Chukwu, OG Ibegbulam, Chukwudi Anigbo, Awele Chukwura, Uche Anike, Osita U Ezenwosu, Augustine Nwakuche Duru, Kingsley Agu, Ifeoma Ajuba, Sunday Ocheni, Anazoeze Jude Madu, Anthony N Ikefuna |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Article Subject Thiocyanate business.industry Thyroid chemistry.chemical_element Iodine Eicosapentaenoic acid Surgery chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Docosahexaenoic acid Internal medicine Potassium thiocyanate medicine Clinical Study Steady state (chemistry) Thyroid function business |
| Zdroj: | ISRN Hematology |
| ISSN: | 2090-441X |
| Popis: | Most people on folic acid to boost erythropoiesis and prophylactic antimicrobials, the standard management of steady state sickle cell disease (SCD), have unacceptable numbers of crises. The objective of this study was to evaluate the effects of adding multimodal therapy with potassium thiocyanate and omega-3 fatty acids to the standard management of steady state SCD. Pre- and post-treatment numbers of crises and other disease indices were compared in 16 HbSS individuals on folic acid and paludrine after 12 months of adding eicosapentaenoic acid 15 mg/kg/day, docosahexaenoic acid 10 mg/kg/day, and potassium thiocyanate 1-2 mL/day, each milliliter of which contained 250 mg of thiocyanate and 100 micrograms of iodine to prevent hypothyroidism: a possible side-effect due to competitive inhibition of the transport of iodide into the thyroid gland by thiocyanate. Median number of crises reduced from 3/yr to 1/yr (P < 0.0001). There was no evidence of impaired thyroid function. Plasma level of tri-iodothyronine improved (P < 0.0001). Steady state full blood count and bilirubin level did not change significantly. The findings suggest that addition of potassium thiocyanate and eicosapentaenoic and docosahexaenoic acids to standard management of steady state SCD reduces the number of crises. This observation needs to be evaluated in larger studies. |
| Databáze: | OpenAIRE |
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