Reduced intake of carbohydrate prevents the development of obesity and impaired glucose metabolism in ghrelin O-acyltransferase knockout mice
| Autor: | Takanori Iwasaki, Nobuteru Akiyama, Shogo Oka, Hideo Yukioka, Tomohiko Okuda, Kumiko Fujieda, Tetsuya Kouno, Isamu Nanchi |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Physiology Administration Oral 030209 endocrinology & metabolism Carbohydrate metabolism Diet High-Fat Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Dietary Carbohydrates medicine Animals Obesity Adiposity Mice Knockout digestive oral and skin physiology Membrane Proteins Fructose Carbohydrate Maltodextrin medicine.disease Ghrelin Ghrelin O-acyltransferase Mice Inbred C57BL Glucose 030104 developmental biology chemistry Carbohydrate Metabolism Metabolic syndrome Energy Intake Acyltransferases Diet Therapy |
| Zdroj: | Peptides. 86:145-152 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/j.peptides.2016.11.003 |
| Popis: | A close relationship between acylated-ghrelin and sucrose intake has been reported. However, little has been examined about the physiological action of ghrelin on preference for different types of carbohydrate such as glucose, fructose, and starch. The current study was aimed to investigate the role of acylated-ghrelin in the determinants of the choice of carbohydrates, and pathogenesis of chronic disorders, including obesity and insulin resistance. In a two-bottle-drinking test, ghrelin O-acyltransferase (GOAT) knockout (KO) mice consumed a less amount of glucose and maltodextrin, and almost the same amount of fructose and saccharin solution compared to WT littermates. The increased consumption of glucose and maltodextrin was observed when acylated-ghrelin, but not unacylated-ghrelin, was exogeneously administered in normal C57BL/6J mice, suggesting an association of acylated-ghrelin with glucose-containing carbohydrate intake. When fed a diet rich in maltodextrin, starch and fat for 12 weeks, GOAT KO mice showed less food intake and weight gain, as well as improved glucose tolerance and insulin sensitivity than WT mice. Our data suggests that blockade of GOAT activity may offer a therapeutic option for treatment of obesity and its associated metabolic syndrome by preventing from overconsumption of carbohydrate-rich food. |
| Databáze: | OpenAIRE |
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