Predictors of presenteeism, absenteeism and job loss in patients commencing methotrexate or biologic therapy for rheumatoid arthritis
| Autor: | Sarah Leggett, James M. Gwinnutt, Anne Barton, Karen Walker-Bone, Kimme L. Hyrich, Braggss co-investigators, Suzanne M M Verstappen, Rams, Mark Lunt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
rheumatoid arthritis
work disability Adult Male medicine.medical_specialty Time Factors Disease Rate ratio Psychological Distress absenteeism Arthritis Rheumatoid Young Adult Sex Factors Rheumatology work Internal medicine medicine Humans Pharmacology (medical) Rheumatoid arthritis AcademicSubjects/MED00360 presenteeism Fatigue Aged Biological Products business.industry Age Factors Odds ratio Clinical Science Middle Aged medicine.disease Methotrexate disability Unemployment Antirheumatic Agents Presenteeism Sick leave Absenteeism Female Sick Leave business medicine.drug |
| Zdroj: | Rheumatology (Oxford, England) Gwinnutt, J, Leggett, S, Lunt, M, Barton, A, Hyrich, K, Walker-Bone, K & Verstappen, S 2020, ' Predictors of presenteeism, absenteeism and job loss in patients commencing methotrexate or biologic therapy for rheumatoid arthritis ', Rheumatology (Oxford) . https://doi.org/10.1093/rheumatology/keaa027 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/keaa027 |
| Popis: | ObjectivesWork is an important health outcome. This study aimed to identify predictors of work loss, absenteeism and presenteeism over 1 year in RA patients commencing treatment with MTX or biologics.MethodsPatients aged 18–65 years in full/part-time employment from two UK prospective cohorts were included: MTX-starters = Rheumatoid Arthritis Medication Study; and biologic-starters = Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate. Presenteeism and absenteeism were assessed using the RA-specific Work Productivity Survey at baseline, and 6 and 12 months. Potential predictors including baseline age, gender, clinical measures (e.g. disability, pain, fatigue), psychological distress, occupation and EULAR response from baseline to 6 months were investigated.ResultsA total of 51/463 MTX-starters and 30/260 biologic-starters left work over 12 months. Higher baseline psychological distress in MTX-starters [odds ratio (OR) 1.1 (95% CI: 1.0, 1.1)] and higher disability in biologic-starters [OR 3.5 (95% CI: 1.4, 8.6)] predicted work loss. Some 16.1% of patients reported sick-leave, which was predicted by disability [OR (95% CI): MTX-starters: 1.5 (0.9, 2.3); biologic-starters: 2.4 (1.1, 5.2)]. Median presenteeism scores were very low (minimal interference) in both cohorts. Higher fatigue for MTX starters [incidence rate ratio 1.2 (95% CI: 1.0, 1.4)] and higher disability in biologic-starters (incidence rate ratio 1.4 (95% CI: 1.1, 1.7)] predicted presenteeism. Good EULAR response was associated with lower absenteeism and presenteeism in both cohorts.ConclusionPatients with RA still face significant limitations regarding their ability to work. Disability and EULAR response were the main predictors of work outcomes, emphasizing the need to control the disease and the importance of function in enabling work participation. |
| Databáze: | OpenAIRE |
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