Increased skeletal muscle expression of the endoplasmic reticulum chaperone GRP78 in patients with myasthenia gravis
| Autor: | Kazuo Iwasa, Masahito Yamada, Yuko Motozaki, Yoshinori Nambu, Yutaka Furukawa, Hiroaki Yoshikawa |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Thymoma Immunology Neuromuscular junction Statistics Nonparametric Young Adult Downregulation and upregulation Internal medicine Myasthenia Gravis medicine Immunology and Allergy Humans RNA Messenger Muscle Skeletal Endoplasmic Reticulum Chaperone BiP Myositis Heat-Shock Proteins Aged Chemistry Endoplasmic reticulum Age Factors Muscle weakness Skeletal muscle Middle Aged medicine.disease Myasthenia gravis Up-Regulation Endocrinology medicine.anatomical_structure Neurology Unfolded protein response Female Neurology (clinical) medicine.symptom |
| Zdroj: | Journal of neuroimmunology. 273(1-2) |
| ISSN: | 1872-8421 |
| Popis: | In myasthenia gravis (MG), damage to neuromuscular junctions may induce endoplasmic reticulum (ER) stress in skeletal muscles. In the current study, skeletal muscles obtained from patients with MG exhibited upregulation of glucose-regulated protein 78 (GRP78) mRNA that was activated by ER stress. Furthermore, GRP78 mRNA expression was higher in patients with MG and myositis than in patients with non-myopathy. We also observed a significant positive correlation between GRP78 mRNA expression and GRP78 protein levels and between GRP78 mRNA expression and age of MG onset. Our findings suggest that muscle weakness in MG might be caused by both neuromuscular junction disruption and ER stress. |
| Databáze: | OpenAIRE |
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