Microfabricated high-throughput electronic particle detector
| Autor: | David K. Wood, Andrew Cleland, M. V. Requa |
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| Rok vydání: | 2007 |
| Předmět: |
Fabrication
Materials science Microfluidics Sensitivity and Specificity Particle detector Coulter counter Miniaturization Electrochemistry Nanotechnology Fluidics Particle Size Instrumentation business.industry Reproducibility of Results Equipment Design Equipment Failure Analysis Flow Injection Analysis Optoelectronics Nanoparticles Radio frequency Particle size Electronics business Microelectrodes |
| Zdroj: | The Review of scientific instruments. 78(10) |
| ISSN: | 0034-6748 |
| Popis: | We describe the design, fabrication, and use of a radio frequency reflectometer integrated with a microfluidic system, applied to the very high-throughput measurement of micron-scale particles, passing in a microfluidic channel through the sensor region. The device operates as a microfabricated Coulter counter [U.S. Patent No. 2656508 (1953)], similar to a design we have described previously, but here with significantly improved electrode geometry as well as including electronic tuning of the reflectometer; the two improvements yielding an improvement by more than a factor of 10 in the signal to noise and in the diametric discrimination of single particles. We demonstrate the high-throughput discrimination of polystyrene beads with diameters in the 4-10 microm range, achieving diametric resolutions comparable to the intrinsic spread of diameters in the bead distribution, at rates in excess of 15 x 10(6) beads/h. |
| Databáze: | OpenAIRE |
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