Recurrence of urinary tract infections and development of urinary-specific antibiogram for kidney transplant recipients
| Autor: | Tirdad T. Zangeneh, Kathryn R. Matthias, Ghazwa B. Korayem |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Cefepime Immunology Population Microbial Sensitivity Tests 030230 surgery Microbiology 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine Drug Resistance Bacterial Escherichia coli medicine Humans Immunology and Allergy 030212 general & internal medicine Intensive care medicine education Escherichia coli Infections Kidney transplantation Aged education.field_of_study business.industry Sulfamethoxazole Middle Aged bacterial infections and mycoses medicine.disease Kidney Transplantation Trimethoprim Transplant Recipients Anti-Bacterial Agents Ciprofloxacin Urinary Tract Infections Ceftriaxone Female Gentamicin business medicine.drug |
| Zdroj: | Journal of Global Antimicrobial Resistance. 12:119-123 |
| ISSN: | 2213-7165 |
| DOI: | 10.1016/j.jgar.2017.08.009 |
| Popis: | Objectives Urinary tract infection (UTI) recurrence and antimicrobial resistance remain a common problem in kidney transplant recipients. Whilst the use of annual institutional antibiograms may help guide appropriate empirical antibiotic selection, these non-disease specific antibiograms do not always account for patient-specific risk factors or disease-specific resistance patterns. This study determined the frequency of UTI recurrence during the first year after kidney transplantation as well as differences in antimicrobial susceptibility between an institutional antibiogram and the disease-specific antibiogram for patients following kidney transplantation. Methods In this study, adult patients with at least one UTI during an inpatient admission within 1 year post kidney transplantation were evaluated. A disease-specific antibiogram for UTIs in kidney transplant recipients was prepared based on culture results and was compared with the annual institutional antibiograms. Results Of 299 kidney transplants performed during the study period, 66 subjects meet the study inclusion criteria, of whom 47% had two or more UTIs within the first year after kidney transplant. In comparison with the institutional antibiogram, Escherichia coli isolated from urine samples from kidney transplant recipients were significantly more resistant to trimethoprim/sulfamethoxazole, ceftriaxone, cefepime, ciprofloxacin and gentamicin (P Conclusions Multiple UTIs are common in kidney transplant recipients during the first year post-transplantation. E. coli urinary isolates were significantly more resistant to multiple antibiotic drug classes in this patient population compared with the general hospital population. Antimicrobial stewardship programmes at transplant centres should consider producing disease-specific antibiograms specifically for transplant recipients to improve empirical antibiotic selection guidance. |
| Databáze: | OpenAIRE |
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