ERK/MAPK signalling in the developing brain: Perturbations and consequences
Autor: | Omowumi Femi-Akinlosotu, Omamuyovwi M. Ijomone, Olayemi K. Ijomone, Joy D. Iroegbu |
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Rok vydání: | 2021 |
Předmět: |
MAPK/ERK pathway
Nervous system Autism Spectrum Disorder Mechanism (biology) Kinase Cognitive Neuroscience Brain Biology Hedgehog signaling pathway Neural stem cell Behavioral Neuroscience Neuropsychology and Physiological Psychology Signalling medicine.anatomical_structure Neural Stem Cells medicine Humans Extracellular Signal-Regulated MAP Kinases Protein kinase A Protein Kinases Neuroscience Signal Transduction |
Zdroj: | Neuroscience & Biobehavioral Reviews. 131:792-805 |
ISSN: | 0149-7634 |
Popis: | The extracellular regulated kinase/microtubule-associated protein kinase (ERK/MAPK) signalling pathway transduces signals that cause an alteration in the ongoing metabolic pathways and modifies gene expression patterns; thus, influencing cellular behaviour. ERK/MAPK signalling is essential for the proper development of the nervous system from neural progenitor cells derived from the embryonic mesoderm. Several signalling molecules that regulate the well-coordinated process of neurodevelopment transduce developmental information through the ERK/MAPK signalling pathway. The ERK/MAPK is a potential novel therapeutic target in several neurodevelopmental disorders, however, despite years of study, there is still significant uncertainty about the exact mechanism by which the ERK/MAPK signalling pathway elicits specific responses in neurodevelopment. Here, we will review the evidence highlighting the role of ERK/MAPK signalling in neurodevelopment. We will also discuss the structural implication and behavioural deficits associated with perturbed ERK/MAPK signalling pathway in cortical development, whilst examining its contribution to the neuropathology of several neurodevelopmental disorders, such as Autism Spectrum Disorder, Schizophrenia, Fragile X, and Attention Deficit Hyperactive Disorder. |
Databáze: | OpenAIRE |
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