From design to the clinic: practical guidelines for translating cardiovascular nanomedicine

Autor: Christoph Alexiou, Pasquale Maffia, Josbert M. Metselaar, Donald Bruce, Didier Letourneur, Iwona Cicha, Janos Szebeni, Cédric Chauvierre, Erik S.G. Stroes, Gert Storm, Neil MacRitchie, László Dézsi, Claudia Cabella, François Rouzet, Isabelle Texier
Přispěvatelé: Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Bracco Research SpA, Bracco, RWTH University Clinic, Semmelweis University [Budapest, Hungary], Service de Médecine Nucléaire [Paris 18eme], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Utrecht University [Utrecht], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Institute of Infection, Immunity and Inflammation, University of Glasgow, Institute of Cardiovascular and Medical Sciences [Glasgow], ACS - Atherosclerosis & ischemic syndromes, Vascular Medicine, Afd Pharmaceutics, Pharmaceutics, Cicha, Iwona, Chauvierre, Cédric, Texier, Isabelle, Cabella, Claudia, Metselaar, Josbert M., Szebeni, Jáno, Dézsi, László, Alexiou, Christoph, Rouzet, Françoi, Storm, Gert, Stroes, Erik, Bruce, Donald, Macritchie, Neil, Maffia, Pasquale, Letourneur, Didier
Rok vydání: 2018
Předmět:
0301 basic medicine
medicine.medical_specialty
Cardiovascular nanomedicine
Clinical translation
Nanoparticle design
Nanosafety
Regulatory issues
Physiology
Regulatory issues
Cardiology
Reviews
Cardiovascular nanomedicine
02 engineering and technology
Nanosafety
Risk Assessment
Translational Research
Biomedical
03 medical and health sciences
Patient safety
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Physiology (medical)
Toxicity Tests
medicine
Animals
Humans
[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics
Nanoparticle design
Intensive care medicine
ComputingMilieux_MISCELLANEOUS
Cardiovascular mortality
business.industry
Clinical translation
021001 nanoscience & nanotechnology
n/a OA procedure
3. Good health
Clinical Practice
Disease Models
Animal
Nanomedicine
030104 developmental biology
Cardiovascular Diseases
Practice Guidelines as Topic
Patient Safety
0210 nano-technology
Cardiology and Cardiovascular Medicine
business
Risk assessment
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Cardiovascular Research
Cardiovascular Research, 2018, 114 (13), pp.1714-1727. ⟨10.1093/cvr/cvy219⟩
Cardiovascular research, 114(13), 1714-1727. Oxford University Press
Cardiovascular Research, Oxford University Press (OUP), 2018, 114 (13), pp.1714-1727. ⟨10.1093/cvr/cvy219⟩
Cardiovascular Research, 114(13), 1714. Oxford University Press
ISSN: 1755-3245
0008-6363
DOI: 10.1093/cvr/cvy219
Popis: Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicom-ponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.
Databáze: OpenAIRE
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