Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy
| Autor: | Hans Jörg Altermatt, Philipp Burri, Ueli Studer, Luca Mazzucchelli, Daniel M. Aebersold, G.ünther Gruber, Valentin Djonov, K. Lindel, Richard H. Greiner |
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| Rok vydání: | 2003 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Multivariate analysis medicine.medical_treatment Brachytherapy Uterine Cervical Neoplasms Adenocarcinoma Disease-Free Survival Internal medicine medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Neoplasm Staging Cervical cancer Analysis of Variance Radiation business.industry Nuclear Proteins Middle Aged Hypoxia (medical) Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Cell Hypoxia Neoplasm Proteins DNA-Binding Proteins Radiation therapy Treatment Outcome Carcinoma Squamous Cell Immunohistochemistry Female Hypoxia-Inducible Factor 1 medicine.symptom business Transcription Factors |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 56:494-501 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(02)04579-0 |
| Popis: | Purpose In the early stages of cervical cancer treated with surgery alone, hypoxia-inducible factor-1α (hif-1α) expression is prognostic for overall survival. Because hypoxia plays an important role in radiation resistance, we investigated hif-1α expression in cervical cancer treated with local radical radiotherapy (RT). Methods and materials Between 1990 and 1998, 91 patients with squamous cell or adenocarcinoma of the uterine cervix were treated with external beam RT with and without brachytherapy. Biopsies from 78 patients were available for immunohistochemistry. The impact of the immunoreactivity of hif-1α in regard to survival end points was determined by univariate and multivariate analyses. Correlations with clinicopathologic characteristics were determined by cross-tabulations. Results Hif-1α was expressed in 73 (94%) of 78 patients. It was closely linked to the pretreatment hemoglobin level ( p = 0.04, r = −0.22, Spearman correlation test). The Kaplan-Meier curves showed a significantly shorter local progression-free survival ( p = 0.04, log–rank) and overall survival ( p = 0.01, log–rank) and a trend for shorter disease-free survival ( p = 0.15) for patients with increased hif-1α expression. The multivariate analyses revealed hif-1α expression to be an independent factor for overall survival ( p = 0.02). Conclusion Hif-1α is expressed in the vast majority of patients with advanced cervical cancer and had a prognostic significance. A weak but significant correlation was noted with pretreatment hemoglobin level. |
| Databáze: | OpenAIRE |
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