Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines
| Autor: | Mark A. Elban, Jean C. Chapuis, Mei Li, Sidney M. Hecht |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Models
Molecular Aporphines Porphyrins Cell Survival Stereochemistry Clinical Biochemistry Drug Evaluation Preclinical Molecular Conformation Pharmaceutical Science Antineoplastic Agents Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Humans Structure–activity relationship Molecular Biology Biological evaluation Biological Products Natural product Molecular Structure Cepharadione B Organic Chemistry Total synthesis Biological activity Isoquinolines chemistry Molecular Medicine DNA |
| Zdroj: | Bioorganic & Medicinal Chemistry. 15:6119-6125 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2007.06.035 |
| Popis: | Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described. |
| Databáze: | OpenAIRE |
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