The Orientation of Gastric Biopsy Samples Improves the Interobserver Agreement of the OLGA Staging System
| Autor: | Mona Dumbrava, Gabriel Becheanu, Bogdan Cotruta, Razvan Iacob, Cristina Radu, Cristian Gheorghe, Ion Bancila |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Gastritis
Atrophic Male medicine.medical_specialty Biopsy Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Cohen's kappa Stomach Neoplasms Humans Medicine Prospective Studies Gastric biopsy Stage (cooking) Aged Neoplasm Staging Observer Variation Metaplasia medicine.diagnostic_test biology business.industry Stomach Gastroenterology Collodion Intestinal metaplasia Middle Aged Helicobacter pylori medicine.disease biology.organism_classification 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Histopathology Gastritis medicine.symptom business Nuclear medicine Precancerous Conditions Filtration |
| Zdroj: | Journal of Gastrointestinal and Liver Diseases. 26:351-356 |
| ISSN: | 1842-1121 1841-8724 |
| DOI: | 10.15403/jgld.2014.1121.264.olg |
| Popis: | Background & Aims: Evaluation of severity and extension of gastric atrophy and intestinal metaplasia is recommended to identify subjects with a high risk for gastric cancer. The inter-observer agreement for the assessment of gastric atrophy is reported to be low. The aim of the study was to evaluate the inter-observer agreement for the assessment of severity and extension of gastric atrophy using oriented and unoriented gastric biopsy samples. Furthermore, the quality of biopsy specimens in oriented and unoriented samples was analyzed.Methods: A total of 35 subjects with dyspeptic symptoms addressed for gastrointestinal endoscopy that agreed to enter the study were prospectively enrolled. The OLGA/OLGIM gastric biopsies protocol was used. From each subject two sets of biopsies were obtained (four from the antrum, two oriented and two unoriented, two from the gastric incisure, one oriented and one unoriented, four from the gastric body, two oriented and two unoriented). The orientation of the biopsy samples was completed using nitrocellulose filters (Endokit®, BioOptica, Milan, Italy). The samples were blindly examined by two experienced pathologists. Inter-observer agreement was evaluated using kappa statistic for inter-rater agreement. The quality of histopathology specimens taking into account the identification of lamina propria was analyzed in oriented vs. unoriented samples. The samples with detectable lamina propria mucosae were defined as good quality specimens. Categorical data was analyzed using chi-square test and a two-sided p value |
| Databáze: | OpenAIRE |
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