Association between low-density lipoprotein cholesterol level and mortality in patients with cardiogenic shock: a retrospective cohort study
| Autor: | Zhewei Shi, Jiali Jin, Xiaomin Pang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Shock Cardiogenic Cardiomyopathy Cardiovascular Medicine Risk Factors Intensive care Internal medicine accident & emergency medicine Humans Medicine Acute Coronary Syndrome Proportional Hazards Models Retrospective Studies business.industry Proportional hazards model Cardiogenic shock Retrospective cohort study Cholesterol LDL General Medicine medicine.disease Pathophysiology cardiology Biomarker (medicine) business cardiomyopathy |
| Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 7 (2021) |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2020-044668 |
| Popis: | AimsInflammation plays a key role in the pathophysiology of cardiogenic shock (CS). Low-density lipoprotein cholesterol (LDL-C) is a biomarker of inflammation and is used to predict prognostic outcomes of several diseases. The primary purpose of this study was to evaluate if LDL-C can be used as a biomarker to predict the mortality of CS.Methods and resultsRecords of critically ill patients with CS were identified from the Medical Information Mart for Intensive Care III database. A multivariate Cox regression model was employed to adjust for imbalances by incorporating parameters and potential confounders.A total of 551 critically ill patients with CS were enrolled for this analysis, including 207 with LDL-C ConclusionsOur study observed that increased LDL-C level was related with improved survival in patients with CS, but not with improved outcomes in patients with uncomplicated ACS. The results need to be verified in randomised controlled trials. |
| Databáze: | OpenAIRE |
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