Long-term pharmacokinetics of amprenavir in combination with delavirdine in HIV-infected children
| Autor: | Guido Kruse, Hartmut Stocker, Bernd H. Belohradsky, Uwe Wintergerst, Carolin Engelhorn, Michael Kurowski, G Notheis, Florian Hoffmann |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adolescent
Anti-HIV Agents Immunology HIV Infections Amprenavir Pharmacokinetics medicine Immunology and Allergy Delavirdine Humans Protease inhibitor (pharmacology) Child Furans Sulfonamides biology Reverse-transcriptase inhibitor biology.organism_classification Virology Reverse transcriptase Drug Combinations Infectious Diseases Area Under Curve Lentivirus Reverse Transcriptase Inhibitors Carbamates Viral load medicine.drug |
| Zdroj: | AIDS (London, England). 18(10) |
| ISSN: | 0269-9370 |
| Popis: | Five heavily pretreated HIV-infected children were put on amprenavir and delavirdine plus two nucleoside inhibitors to reverse transcriptase to boost amprenavir levels and to use the antiretroviral activity of a non-nucleoside reverse transcriptase inhibitor. No data are available about this combination in children. It w;as well tolerated, and the median reduction in viral load was 1.5 log after 18 months. Delavirdine boosted amprenavir trough levels more than 10-fold, and delavirdine trough levels remained i several fold above susceptible HIV strains. |
| Databáze: | OpenAIRE |
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