Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices
| Autor: | Maria Butnaru, Laura Knieling, Stelian Vlad, Daniela Filip, Doina Macocinschi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Ketoprofen Biocompatibility Polyurethanes 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry chemistry.chemical_compound Structural Biology Desorption Absorbable Implants Materials Testing medicine Polytetrahydrofuran Animals Humans Organic chemistry Cellulose Molecular Biology Cells Cultured Cell Proliferation Polyurethane Inflammation Hydroxypropyl cellulose Anti-Inflammatory Agents Non-Steroidal Sorption General Medicine 021001 nanoscience & nanotechnology Rats 0104 chemical sciences chemistry 0210 nano-technology medicine.drug Nuclear chemistry |
| Zdroj: | International Journal of Biological Macromolecules. 52:32-37 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2012.09.026 |
| Popis: | A polyether-urethane based on polytetrahydrofuran containing hydroxypropyl cellulose for biomedical applications was tested for its biocompatibility. Ketoprofen was incorporated (3% and 6%) in the polyurethane matrix as an anti-inflammatory drug. Dynamic vapour sorption method was employed for testing the water sorption/desorption behaviour of these materials with the determination of the surface isotherms, surface parameters and the kinetic curves of sorption/desorption processes. Cytotoxicity testing in vitro for quantifying cell proliferation was employed, and the results evidence noncytotoxicity for the studied polyurethane–drug systems. In vivo biocompatibility study was performed on 200 g weight male rats. It was found that after implantation of the polyether-urethane samples a reduced acute inflammation occurred, especially for polyurethane samples with added ketoprofen. |
| Databáze: | OpenAIRE |
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