Increased Reward-Related Activation in the Ventral Striatum During Stress Exposure Associated With Positive Affect in the Daily Life of Young Adults With a Family History of Depression. Preliminary Findings
| Autor: | Chantal Martin-Soelch, Matthias Guillod, Claudie Gaillard, Romina Evelyn Recabarren, Andrea Federspiel, Christoph Mueller-Pfeiffer, Philipp Homan, Gregor Hasler, Dominik Schoebi, Antje Horsch, Patrick Gomez |
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| Přispěvatelé: | University of Zurich, Martin-Soelch, Chantal |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:RC435-571 Offspring striatum 610 Medicine & health negative affect (NA) Striatum Asymptomatic 050105 experimental psychology 2738 Psychiatry and Mental Health stress 03 medical and health sciences 0302 clinical medicine Neuroimaging lcsh:Psychiatry Internal medicine Medicine 0501 psychology and cognitive sciences Family history Young adult reward Depression (differential diagnoses) Original Research Psychiatry business.industry fMRI 05 social sciences Ventral striatum Psychiatry and Mental health ambulatory assessment (AA) depression positive affect (PA) medicine.anatomical_structure Endocrinology 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics medicine.symptom business psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Psychiatry, Vol 11 (2021) Frontiers in Psychiatry Frontiers in psychiatry, vol. 11, pp. 563475 |
| ISSN: | 1664-0640 |
| Popis: | Background:Being the offspring of a parent with major depression disorder (MDD) is a strong predictor for developing MDD. Blunted striatal responses to reward were identified in individuals with MDD and in asymptomatic individuals with family history of depression (FHD). Stress is a major etiological factor for MDD and was also reported to reduce the striatal responses to reward. The stress-reward interactions in FHD individuals has not been explored yet. Extending neuroimaging results into daily-life experience, self-reported ambulatory measures of positive affect (PA) were shown to be associated with striatal activation during reward processing. A reduction of self-reported PA in daily life is consistently reported in individuals with current MDD. Here, we aimed to test (1) whether increased family risk of depression is associated with blunted neural and self-reported reward responses. (2) the stress-reward interactions at the neural level. We expected a stronger reduction of reward-related striatal activation under stress in FHD individuals compared to HC. (3) the associations between fMRI and daily life self-reported data on reward and stress experiences, with a specific interest in the striatum as a crucial region for reward processing.Method:Participants were 16 asymptomatic young adults with FHD and 16 controls (HC). They performed the Fribourg Reward Task with and without stress induction, using event-related fMRI. We conducted whole-brain analyses comparing the two groups for the main effect of reward (rewarded > not-rewarded) during reward feedback in control (no-stress) and stress conditions. Beta weights extracted from significant activation in this contrast were correlated with self-reported PA and negative affect (NA) assessed over 1 week.Results:Under stress induction, the reward-related activation in the ventral striatum (VS) was higher in the FHD group than in the HC group. Unexpectedly, we did not find significant group differences in the self-reported daily life PA measures. During stress induction, VS reward-related activation correlated positively with PA in both groups and negatively with NA in the HC group.Conclusion:As expected, our results indicate that increased family risk of depression was associated with specific striatum reactivity to reward in a stress condition, and support previous findings that ventral striatal reward-related response is associated with PA. A new unexpected finding is the negative association between NA and reward-related ventral striatal activation in the HC group. |
| Databáze: | OpenAIRE |
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