Antibiotic activity of isoxazolylnaphthoquinone imines on mice infected withStaphylococcus aureus
| Autor: | Alberto Jorge Eraso, Patricia Bogdanov, M. M. De Bertorello, Norma R. Sperandeo, Inés Albesa |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Micrococcaceae medicine.drug_class Antibiotics Microbial Sensitivity Tests Naphthols medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Mice Minimum inhibitory concentration Anti-Infective Agents medicine Animals Escherichia coli Mice Inbred BALB C Molecular Structure biology Pseudomonas aeruginosa Isoxazoles Staphylococcal Infections biology.organism_classification Antimicrobial Enterobacteriaceae Staphylococcus aureus Female Naphthoquinones |
| Zdroj: | Journal of Applied Bacteriology. 78:373-377 |
| ISSN: | 0021-8847 |
| DOI: | 10.1111/j.1365-2672.1995.tb03420.x |
| Popis: | I. ALBESA, P. BOGDANOV, A. ERASO, N.R. SPERANDEO AND M.M. DE BERTORELLO. 1995. The antibiotic activity of new synthetic isoxazolylnaphthoquinone imines was studied. Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 were resistant to the four compounds studied (MIC > 128 µg ml−1), but Staphylococcus aureus ATCC 25923, ATCC 29213 and 30 clinical isolates of Staph. aureus were inhibited by 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine (I). This compound diminished bloodstream infection of mice injected i.m. with Staph. aureus; septicaemia decayed significantly when I was applied at the beginning of the infection while when I was given 3 d after bacterial challenge, a significant protection was afforded. Bactericidal activity in serum increased during the 5 h after I was administered i.p. The acetyl derivative of I had a high MIC but when inoculated orally in mice decreased the Staph. aureus counts in circulation. This protection occurred only when the schedule of administration started close to the bacterial challenge. Antibiotic activity in vivo may be associated with in vitro effects. |
| Databáze: | OpenAIRE |
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