del(5q) in acute lymphoblastic leukemia with biphenotypic and early progenitor phenotype
| Autor: | Eva Perdahl-Wallace, Vesna Najfeld, Chris Theodossiou, Lewis B. Silverman, Angela Scalise, Kevin Troy |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent Lymphoblastic Leukemia Biology Immunophenotyping Internal medicine Acute lymphocytic leukemia Genetics medicine Humans Molecular Biology Aged Progenitor Stem Cells Cytogenetics Karyotype Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis medicine.disease Phenotype Immunology Chromosomes Human Pair 5 Chromosome Deletion Abnormality |
| Zdroj: | Cancer Genetics and Cytogenetics. 63:89-94 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(92)90385-l |
| Popis: | We report three patients with acute lymphoblastic leukemia with biphenotypic and early progenitor phenotype who had del(5q). In the first patient, the del(5q) was the sole abnormality; in the second patient, the del(5q) was interpreted as subclonal evolutionary event; while in the third patient, the rearrangement was transiently present 7 months following the diagnosis of Ph-positive ALL, while the patient was in clinical remission. Review of the literature indicates that del(5q) is rare in ALL. In contrast to its presence in AML, del(5q) in ALL is not an adverse prognostic indicator, and it appears to be more frequent in children. |
| Databáze: | OpenAIRE |
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