Evaluation of hs-CRP and visseral adiposity index in patients with policystic ovary syndrome by clinical and laboratory findings

Autor: Ahmet Beyazit, Burak Un, Hanifi Şahin, Kenan Dolapçıoğlu, A. Güler Okyay
Přispěvatelé: Zonguldak Bülent Ecevit Üniversitesi
Rok vydání: 2016
Předmět:
Adult
Blood Glucose
Cardiovascular disease marker
medicine.medical_specialty
Waist
Adolescent
Urinary system
medicine.medical_treatment
030204 cardiovascular system & hematology
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
Sex hormone-binding globulin
Risk Factors
Sex Hormone-Binding Globulin
Internal medicine
Follicular phase
PCOS
Humans
Insulin
Medicine
Outpatient clinic
Testosterone
Adiposity
030219 obstetrics & reproductive medicine
Estradiol
biology
business.industry
Obstetrics and Gynecology
Venous blood
Luteinizing Hormone
Visceral adiposity index (VAI)
hs-CRP
C-Reactive Protein
Endocrinology
Reproductive Medicine
Cardiovascular Diseases
biology.protein
Female
Follicle Stimulating Hormone
Insulin Resistance
business
Body mass index
Polycystic Ovary Syndrome
Zdroj: European Journal of Obstetrics & Gynecology and Reproductive Biology. 204:16-20
ISSN: 0301-2115
DOI: 10.1016/j.ejogrb.2016.06.022
Popis: WOS: 000385321900004
PubMed: 27479317
Aim: In this study, we aimed to evaluate two cardiovascular risk markers, hs-CRP and visseral adiposity index, in patients with policystic ovary syndrome in association with clinical and laboratory findings. Material and method: Study group included 75 patients who were diagnosed as PCOS according to the criteria of AE-PCOS 2006 and control group included 75 non-PCOS patients who were subsequently admitted to outpatient clinic for smear control, with urinary or vaginal symptoms. Physical and sonographic examinations were made to all subjects. Mean arterial pressure, waist/hip ratio and body mass index were calculated. Fasting blood glucose and insulin, HbA1c, lipids, high sensitivity C-reactive protein (hs-CRP), estradiol, follicle stimulating hormon, luteinising hormone, timid stimulating hormone, prolaktin, total testosteron and sex hormone binding globulin were tested in venous blood samples collected from cases following overnight fast in follicular phase of spontaneous or induced menstruation. Visceral adiposity index was also calculated. Findings: No statistically significant difference was found between PCOS group and control group concerning hs-CRP and VAI (p > 0.05). When patients in PCOS group were further grouped as obese and non-obese, hs-CRP and VAI values in obese group were significantly higher than those in non-obese. group (p < 0.001). However, when control group were further grouped as obese and non-obese, there was no significant difference in terms of hs-CRP between groups (p > 0.05), VAI values were significantly higher in obese control group (p < 0.05). Conclusion: According to the results of our study, hs-CRP stands for a better and more specific marker than VAI to determine metabolic components and predictive risks for cardiovascular diseases in patients with PCOS. Further studies with larger populations are needed in order to determine cardiovascular risks particularly in young PCOS patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Databáze: OpenAIRE
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