Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery—Building chiral technology toolboxes
| Autor: | Li Di, Leonard A. McDonald, Mairead Young, Lisa Nogle, Dahui Zhou, Brian L. Marquez, Mei-Yi Zhang, William L. Watts, Frank E. Koehn, Alvin C. Bach, Yanxuan Cai, Alan G. Sutherland, Neal Byrne, Guy T. Carter, Michael Z. Kagan, Edward H. Kerns, Mark Tischler, Carl J. Balibar, Oliver J. McConnell, Igor Goljer, Gerhard Schlingmann, Yanan He, Don Herold, Douglas M. Ho, Michael Chlenov, Christopher J. Petucci, R. Thomas Williamson, Gregory J. Tawa, Yingru Zhang, Vasilios Marathias, Christina M. Kraml, Kristi Fan |
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| Rok vydání: | 2007 |
| Předmět: |
Magnetic Resonance Spectroscopy
Drug Industry Stereochemistry Chemistry Pharmaceutical Molecular Conformation Electrons Catalysis Analytical Chemistry Prochirality Drug Discovery Humans Technology Pharmaceutical Optical rotation Chiral derivatizing agent Spectroscopy Pharmacology Chromatography Drug discovery Chemistry Circular Dichroism Organic Chemistry Absolute configuration Enantioselective synthesis Stereoisomerism Models Chemical Drug Design Supercritical fluid chromatography Salts Enantiomer |
| Zdroj: | Chirality. 19:658-682 |
| ISSN: | 1520-636X 0899-0042 |
| DOI: | 10.1002/chir.20399 |
| Popis: | The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to successfully discovering and developing chiral drugs in the pharmaceutical industry. This has been due to the rapid increase over the past 10-15 years in potential drug candidates containing one or more asymmetric centers. Based on the experiences of one pharmaceutical company, a summary of the establishment of a Chiral Technology toolbox, including the implementation of known tools as well as the design, development, and implementation of new Chiral Technology tools, is provided. |
| Databáze: | OpenAIRE |
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