Surface Modifications of an Organic Polymer-Based Microwire Platform for Sustained Release of an Anti-Inflammatory Drug
| Autor: | Sebastian Duque, Melissa Franklin, Gabriel A Blanco Colmenares, Anabel Álvarez-Ciara, Chuan Liu, Jean Hubert Olivier, Abhishek Prasad, Justin Benito Domena, Cassie Bennett, Aisha F Chebbi, Brianna Bernard, Noah C Kleinhenz, Michelle A. Nguyen |
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| Rok vydání: | 2022 |
| Předmět: |
Nervous system
Drug Organic polymer business.industry medicine.drug_class media_common.quotation_subject Biochemistry (medical) Biomedical Engineering General Chemistry Pharmacology medicine.disease Anti-inflammatory Biomaterials medicine.anatomical_structure Medicine Surface modification Amyotrophic lateral sclerosis business Stroke Spinal cord injury media_common |
| Zdroj: | ACS applied bio materials. 3(7) |
| ISSN: | 2576-6422 |
| Popis: | Brain machine interfaces (BMIs), introduced into the daily lives of individuals with injuries or disorders of the nervous system such as spinal cord injury, stroke, or amyotrophic lateral sclerosis, can improve the quality of life. BMIs rely on the capability of microelectrode arrays to monitor the activity of large populations of neurons. However, maintaining a stable, chronic electrode-tissue interface that can record neuronal activity with a high signal-to-noise ratio is a key challenge that has limited the translation of such technologies. An electrode implant injury leads to a chronic foreign body response that is well-characterized and shown to affect the electrode-tissue interface stability. Several strategies have been applied to modulate the immune response, including the application of immunomodulatory drugs applied both systemically and locally. While the use of passive drug release at the site of injury has been exploited to minimize neuroinflammation, this strategy has all but failed as a bolus of anti-inflammatory drugs is released at predetermined times that are often inconsistent with the ongoing innate inflammatory process. Common strategies do not focus on the proper anchorage of soft hydrogel scaffolds on electrode surfaces, which often results in delamination of the porous network from electrodes. In this study, we developed a microwire platform that features a robust yet soft biocompatible hydrogel coating, enabling long-lasting drug release via formation of drug aggregates and dismantlement of hydrophilic biodegradable three-dimensional polymer networks. Facile surface chemistry is developed to functionalize polyimide-coated electrodes with the covalently anchored porous hydrogel network bearing large numbers of highly biodegradable ester groups. Exponential long-lasting drug release is achieved using such hydrogels. We show that the initial state of dexamethasone (Dex) used to formulate the hydrogel precursor solution plays a cardinal role in engineering hydrophilic networks that enable a sustained and long-lasting release of the anti-inflammatory agent. Furthermore, utilization of a high loading ratio that exceeds the solubility of Dex leads to the encapsulation of Dex aggregates that regulate the release of this anti-inflammatory agent. To validate the anti-inflammatory effect of the hydrogel-functionalized Dex-loaded microwires, an |
| Databáze: | OpenAIRE |
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