Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
| Autor: | Michał Kloska, Nadia Sawicka-Gutaj, Marek Ruchała, Jerzy Sowiński, Ariadna Zybek-Kocik, Dorota Mańkowska-Wierzbicka, Aleksandra Klimowicz |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Article Subject endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism medicine.disease_cause lcsh:Diseases of the endocrine glands. Clinical endocrinology Autoimmunity Autoimmune thyroiditis 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Internal medicine medicine Thyroid cancer lcsh:RC648-665 biology Endocrine and Autonomic Systems business.industry Insulin medicine.disease Anti-thyroid autoantibodies 030220 oncology & carcinogenesis Thyroid hormones Clinical Study biology.protein Antibody business |
| Zdroj: | International Journal of Endocrinology International Journal of Endocrinology, Vol 2016 (2016) |
| ISSN: | 1687-8345 1687-8337 |
| Popis: | We hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis. This is a prospective case-control study of 118 subjects. The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thyroiditis. The nonautoimmune study group (TT) consisted of 40 patients thyroidectomized due to the differentiated thyroid cancer staged pT1. The control group comprised 39 healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies. Exclusion criteria consisted of other autoimmune diseases, active neoplastic disease, diabetes mellitus, and infection, which were reported to alter visfatin level. Fasting blood samples were taken for visfatin, TSH, free thyroxine (FT4), free triiodothyronine (FT3), antithyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), glucose, and insulin levels. The highest visfatin serum concentration was in AIT group, and healthy controls had visfatin level higher than TT (p=0.0001). Simple linear regression analysis revealed that visfatin serum concentration was significantly associated with autoimmunity (β=0.1014;p=0.003), FT4 (β=0.05412;p=0.048), FT3 (β=0.05242;p=0.038), and TPOAb (β=0.0002;p=0.0025), and the relationships were further confirmed in the multivariate regression analysis. |
| Databáze: | OpenAIRE |
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