Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka

Autor: Madhubhani Hemachandra, Kazutoshi Fujioka, Mayumi Ishizuka, H M Ayala S Herath, S. K. Weragoda, Kumiko Taira, Yoshiko Aoyama, Yoshinori Ikenaka, Tomonori Kawakami, Makiko Komori, Nirmalie Pallewatta, Jean-Marc Bonmatin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Insecticides
Pyridines
Thiazines
urologic and male genital diseases
Guanidines
Gastroenterology
Dinotefuran
Neonicotinoids
chemistry.chemical_compound
Tandem Mass Spectrometry
Chronic kidney disease
Surveys and Questionnaires
Farmers
Multidisciplinary
Geography
Middle Aged
Nitro Compounds
Thiacloprid
Diarrhea
Kidney Tubules
Medicine
Female
medicine.symptom
Thiamethoxam
Adult
Quality Control
medicine.medical_specialty
Urinary system
Science
Urinalysis
Fatty Acid-Binding Proteins
Article
Renal tubular dysfunction
Internal medicine
Interstitial nephritis
medicine
Humans
Pharmacokinetics
Cystatin C
Renal Insufficiency
Chronic
Sri Lanka
business.industry
Neonicotinoid
Diagnostic markers
medicine.disease
Thiazoles
chemistry
Etiology
Nervous System Diseases
business
Biomarkers
Chromatography
Liquid
Kidney disease
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
ISSN: 2045-2322
Popis: Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To elucidate the relationship between renal tubular dysfunctions and urinary neonicotinoids concentrations, we collected spot urine samples from15 CKD patients, 15 family members, and 62 neighbors in 2015, analyzed two renal tubular biomarkers, Cystatin-C and L-FABP, quantified seven neonicotinoids and a metabolite N-desmethyl-acetamiprid by LC–MS/MS; and we investigated their symptoms using a questionnaire. Cystatin-C and L-FABP had a positive correlation (p N-Desmethyl-acetamiprid was detected in 92.4% of the urine samples, followed by dinotefuran (17.4%), thiamethoxam (17.4%), clothianidin (9.8%), thiacloprid and imidacloprid. Dinotefuran and thiacloprid have never been registered in Sri Lanka. In High Cystatin-C group (> 70 μg/gCre, n = 7), higher urinary concentration of dinotefuran (p = 0.009), and in Zero Cystatin-C group (N-desmethyl-acetamiprid (p = 0.013), dinotefuran (p = 0.049), and thiacloprid (p = 0.035), and more complaints of chest pains, stomachache, skin eruption and diarrhea (p
Databáze: OpenAIRE
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