Haptoglobin Gene Polymorphism among Sickle Cell Patients in West Cameroon: Hematological and Clinical Implications
| Autor: | Jean Paul Chedjou, Carine Nguemeni, Samuel Ashusong, Constant Anatole Pieme, Jocelyn Tony Nengom, Donatien Gatsing, Georges Teto, Prosper Cabral Biapa Nya, Christian Bernard Kengne Fotsing, Gisele Njindam, Wilfred Fon Mbacham |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Article Subject medicine.diagnostic_test biology business.industry Haptoglobin Complete blood count Hematology Gastroenterology law.invention Polymorphism (computer science) law Internal medicine Genotype medicine biology.protein Diseases of the blood and blood-forming organs Hemoglobin RC633-647.5 Allele Lipid profile business Polymerase chain reaction Research Article |
| Zdroj: | Advances in Hematology Advances in Hematology, Vol 2021 (2021) |
| ISSN: | 1687-9104 |
| Popis: | Haptoglobin is a protein involved in protecting the body from the harmful effects of free hemoglobin. The haptoglobin gene exhibits a polymorphism, and the different genotypes do not have the same capacity to combat the free hemoglobin effects. The present study aimed at determining the polymorphic distribution of haptoglobin in sickle cell patients (SCPs) from West Cameroon and their impact on the hematological parameters, as well as clinical manifestations of the disease severity. Haptoglobin genotype of 102 SCPs (SS) and 115 healthy individuals (60 AA and 55 AS) was determined by allele-specific polymerase chain reaction, and the complete blood count was determined using the AutoAnalyser. Results showed that the genotype Hp2-2 was significantly ( p p |
| Databáze: | OpenAIRE |
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